Hydroxytyrosol Prevents Doxorubicin-Induced Oxidative Stress and Apoptosis in Cardiomyocytes

Hydroxytyrosol Prevents Doxorubicin-Induced Oxidative Stress and Apoptosis in Cardiomyocytes

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Doxorubicin (Dox) is a highly effective chemotherapeutic agent employed in the handling of hematological and solid tumors.The effective use of Dox in cancer therapy has been seriously limited due to its well-known cardiotoxic side effects, mainly mediated by oxidative damage.Therefore, the identification of an effective and safe antagonist against Dox-induced cardiotoxicity remains a challenge.

In this respect, as plant polyphenols have attracted considerable interest ellakai due to their antioxidant properties and good safety profile, hydroxytyrosol (HT), the major phenolic compound in olive oil, could be a potential candidate due to its remarkable antioxidant and anticancer powers.In this study, the effect of HT was tested on Dox-induced cardiotoxicity by using a combination of biochemical and cellular biology techniques.Interestingly, HT was able to counteract Dox-induced cytotoxicity in cardiomyocytes by acting on the SOD2 level and the oxidative response, as well as on apoptotic mechanisms mediated by Bcl-2/Bax.

At the same time, HT did not to interfere with the antitumorigenic properties of Dox in osteosarcoma cells.This study identifies new, beneficial properties for HT and suggests that it might be a promising molecule for the sastra bandham vel online shopping development of additional therapeutic approaches aimed at preventing anthracycline-related cardiotoxicity and improving long-term outcomes in antineoplastic treatments.